Sobre o TEV

O tromboembolismo venoso (TEV) se caracteriza pela formação de trombos nas veias profundas, com obstrução parcial ou total, sendo mais frequente o acometimento dos membros inferiores, ao redor de 80% a 95% dos casos.1 Constitui uma complicação grave em pacientes hospitalizados e a causa mais frequente de morte evitável nesses pacientes, além de ser a terceira causa de morte de origem cardiovascular, após a doença arterial coronariana e o acidente vascular cerebral.2 Numerosas situações clínicas ou cirúrgicas aumentam o risco de TEV. A imobilização dos membros inferiores por mais de três dias aumenta o risco em até 10 vezes;3 10% a 30% dos pacientes internados por doenças clínicas agudas podem apresentar TEV;4 a insuficiência cardíaca e a insuficiência respiratória aumentam o risco trombótico em até 10 vezes.5 Esses dados reforçam a importância da tromboprofilaxia, tanto para pacientes clínicos como cirúrgicos.

Fatores de risco para TEV

  • Imobilidade
  • Cirurgia (particularmente ortopédica)

A artroplastia total do joelho (ATJ) e a de quadril (ATQ) são procedimentos cirúrgicos para aliviar a dor e melhorar a função prejudicada das articulações. Apesar de esses procedimentos serem seguros, a trombose venosa profunda (TVP) e a tromboembolia pulmonar (TEP) são potenciais complicações. Estudo observacional prospectivo usando venografia de membro inferior bilateral na primeira semana de pósoperatório encontrou uma elevada incidência de TVP sintomática (4,6%) e TVP assintomática (18,3%) em pacientes submetidos a artroplastia de joelho.9 Caprini e cols.10 Encontraram, por meio de Doppler de membros inferiores realizado uma e quatro semanas após cirurgia de ATQ, uma taxa elevada de TVP (15,2%), apesar do uso meias elásticas, heparina e varfarina após alta hospitalar, dos quais 64% eram assintomáticos, sendo 31,6% detectados na primeira semana e 68%, um mês após a cirurgia.

  • Câncer
  • Uso de estrogênio
  • Gravidez e puerpério
  • Idade avançada (>65 anos)
  • Obesidade
  • Distúrbios hereditários/idiopáticos pró-trombóticos da coagulação – resistência à proteína C ativada (principalmente fator V de Leiden); mutação do gene da protrombina G20210A; deficiência de antitrombina; deficiência de proteína C; deficiência de proteína S; hiper-homocisteinemia; aumento do fator VIII; aumento do fibrinogênio

Complicações

Insuficiência venosa crônica/síndrome pós-trombótica (edema e/ou dor em membros inferiores, mudança na pigmentação e ulcerações na pele).

TEP com elevado risco de morte. Aproximadamente 5% a 15% de indivíduos não tratados da TVP podem morrer de embolia pulmonar.2

Referências

  1. Bates SM, Jaeschke R, Stevens SM, Goodacre S, Wells PS, Stevenson MD, et al. Diagnosis of DVT: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e351S-418S.

  2. Beckman MG, Hooper WC, Critchley SE, Ortel TL. Venous thromboembolism: a public health concern. Am J Prev Med. 2010;38(4 Suppl):S495-501.

  3. Heit JA, Silverstein MD, Mohr DN, Petterson TM, O’Fallon WM, Melton LJ 3rd. Risk factors for deep vein thrombosis and pulmonary embolism: a populationbased case-control study. Arch Intern Med. 2000;160(6):809-15.

  4. Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama CM, Lassen MR, et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133(6 Suppl):381S-453S.

  5. Anderson FA Jr, Spencer FA. Risk factors for venous thromboembolism. Circulation. 2003;107(23 Suppl 1):I9-16.

  6. Mcmanus RJ, Fitzmaurice DA, Murray E, Taylor C. Thromboembolism. BMJ Clin Evid. 2011;2011:0208.

  7. Lopes LC, Eikelboom J, Spencer FA, Akl EA, Kearon C, Neumann I, et al. Shorter or longer anticoagulation to prevent recurrent venous thromboembolism: systematic review and meta-analysis. BMJ Open. 2014;4(7):e005674.

  8. Streiff MB. Predicting the risk of recurrent venous thromboembolism (VTE). J Thromb Thrombolysis. 2015;39(3):353-66.

  9. Song K, Xu Z, Rong Z, Yang X, Yao Y, Shen Y, et al. The incidence of venous thromboembolism following total knee arthroplasty: a prospective study by using computed tomographic pulmonary angiography in combination with bilateral lower limb venography. Blood Coagul Fibrinolysis. 2016;27 (3):266-9.

  10. Caprini JA, Arcelus JI, Motykie G, Kudrna JC, Mokhtee D, Reyna JJ. The influence of oral anticoagulation therapy on deep vein thrombosis rates four weeks after total hip replacement. J Vasc Surg. 1999;30(5):813-20.

  11. Barros MVL, Pereira VSR, Pinto DM. Controversies in the diagnosis and treatment of deep vein thrombosis for vascular ultrasound. J Vas Bras. 2012;11(2):137-43.

  12. Osman AA, Ju W, Sun D, Qi B. Deep venous thrombosis: a literature review. Int J Clin Exp Med, 2018;11(3):1551-61.

  13. Wells PS, Anderson DR, Bormanis J, Guy F, Mitchell M, Gray L, et al. Value of assessment of pretest probability of deep-vein thrombosis in clinical management. Lancet. 1997;350(9094):1795-8.

  14. Wells PS, Anderson DR, Rodger M, Ginsberg JS, Kearon C, Gent M, et al. Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer. Thromb Haemost. 2000;83(3):416-20.

  15. Hirsh J, Lee AY. How we diagnose and treat deep vein thrombosis. Blood. 2002;99(9):3102-10.

  16. Guyatt GH, Akl EA, Crowther M, Gutterman DD, Schuunemann HJ. Executive summary: antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 2012;141(2 Suppl):7S-47S.

  17. English WJ, Williams DB, Soto FC. Thromboembolic disease in the bariatric patient: prevention, diagnosis, and management. In: Herron DM. Bariatric Surgery Complications and Emergencies. New York, NY: Springer International Publishing; 2016. p. 51-71.

  18. Rahme E, Dasgupta K, Burman M, Yin H, Bernatsky S, Berry G, et al. Postdischarge thromboprophylaxis and mortality risk after hip-or knee-replacement surgery. CMAJ. 2008;178(12):1545-54.

  19. Collins R, Scrimgeour A, Yusuf S, Peto R. Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. Overview of results of randomized trials in general, orthopedic, and urologic surgery. N Engl J Med. 1988;318(18):1162-73.

  20. Raymundo SRO, Lobo SMA, Hussain KMK, Hussein KG, Secches IT. What has changed in venous thromboembolism prophylaxis for hospitalized patients over recent decades: review article. J Vasc Bras. 2019;18:e20180021.

  21. Samama CM, Vray M, Barré J, Fiessinger JN, Rosencher N, Lecompte T, et al. Extended venous thromboembolism prophylaxis after total hip replacement: a comparison of low-molecular-weight heparin with oral anticoagulant. Arch Intern Med. 2002;162(19):2191-6.

  22. Cohen AT, Davidson BL, Gallus AS, Lassen MR, Prins MH, Tomkowski W, et al. Efficacy and safety of fondaparinux for the prevention of venous thromboembolism in older acute medical patients: randomised placebo controlled trial. BMJ. 2006;332(7537):325-9.

  23. Agnelli G, Bergqvist D, Cohen AT, Gallus AS, Gent M. Randomized clinical trial of postoperative fondaparinux versus perioperative dalteparin for prevention of venous thromboembolism in high-risk abdominal surgery. Br J Surg. 2005;92(10):1212-20.

  24. Turpie AG, Bauer KA, Eriksson BI, Lassen MR. Fondaparinux vs enoxaparin for the prevention of venous thromboembolism in major orthopedic surgery: a metaanalysis of 4 randomized double-blind studies. Arch Intern Med. 2002;162(16):1833-40.

  25. Eriksson BI, Dahl OE, Rosencher N, Kurth AA, van Dijk CN, Frostick SP, et al. Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial. J Thromb Haemost. 2007;5(11):2178-85.

  26. Eriksson BI, Dahl OE, Rosencher N, Kurth AA, van Dijk CN, Frostick SP, et al.; RE-NOVATE Study Group. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial. Lancet. 2007;370(9591):949-56.

  27. Eriksson BI, Dahl OE, Huo MH, Kurth AA, Hantel S, Hermansson K, et al.; RE-NOVATE II Study Group. Oral dabigatran versus enoxaparin for thromboprophylaxis after primary total hip arthroplasty (RE-NOVATE II*). A randomised, double-blind, non-inferiority trial. Thromb Haemost. 2011;105(4):721-9.

  28. Eriksson BI, Dahl OE, Rosencher N, Clemens A, Hantel S, Feuring M, et al. Oral dabigatran etexilate versus enoxaparin for venous thromboembolism prevention after total hip arthroplasty: pooled analysis of two phase 3 randomized trials. Thromb J. 2015;13:36.

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