![What lies beneath in dedifferentiated liposarcoma (DDLPS)?](/disease/oncology/beneath-ddlps/sites/default/files/2024-04/Beaneath_DDLPS_Banner.jpeg)
What lies beneath in dedifferentiated liposarcoma (DDLPS)?
Look below the surface in DDLPS
When we discover what lies beneath, a fuller picture takes shape
For nearly 50 years, the standard of care for locally advanced (unresectable) and/or metastatic DDLPS has not changed significantly. DDLPS is a liposarcoma subtype that poses a formidable challenge and is characterised by its local recurrence rates and poor overall prognosis.1-3
![Diagnosis magnifying glass icon Diagnosis magnifying glass icon](/disease/oncology/beneath-ddlps/sites/default/files/2024-03/Look_deeper.jpeg)
DDLPS is an aggressive subtype of liposarcoma comprising 15-20% of diagnosed liposarcoma cases2,4
![Tumor cell icon Tumor cell icon](/disease/oncology/beneath-ddlps/sites/default/files/2024-03/Uncover_the_challenge.jpeg)
DDLPS is associated with poor prognosis and limited treatment options in advanced disease2,3
![Microscope icon Microscope icon](/disease/oncology/beneath-ddlps/sites/default/files/2024-03/Explore_DDLPS_diagnosis.jpeg)
Frequently seen in the retroperitoneum, the route to diagnosis for DDLPS is challenging2,5
![DDLPS HCP team DDLPS HCP team](/disease/oncology/beneath-ddlps/sites/default/files/2024-03/Learn_about_collaboration.jpeg)
A multidisciplinary approach is recommended for the diagnosis and management of DDLPS3,7
References:
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Italiano A. Cancer Discov. 2023;13(8):1765-1767.
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Gahvari Z, Parkes A. Curr Treat Options Oncol. 2020;21(2):15. doi:10.1007/s11864-020-0705-7
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McGovern Y, Zhou CD, Jones RL. Front Oncol. 2017;7:292. doi:10.3389/fonc.2017.00292
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Schöffski P. Oncol Res Treat. 2022;45(9):525-543.
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Soomers VLMN, van der Graaf WTA, Zaidi S, et al. PLoS One. 2020;15(12):e0243439. doi:10.1371/journal.pone.0243439
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Langmans C, Cornillie J, van Cann T, et al. Oncol Res Treat. 2019;42(7-8):396-403.
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Gamboa AC, Gronchi A, Cardona K. CA Cancer J Clin. 2020;70(3):200-229.