Generalized Pustular Psoriasis (GPP) | Generalized Pustular Psoriasis (GPP) Egypt

WHEN YOU SEE IT, BE PREPARED

Generalized Pustular Psoriasis (GPP) is a rare and potentially life-threatening skin disease¹ distinct from Plaque Psoriasis.²Caused by dysregulation of the IL36- pathway,³GPP flares can affect every aspect of a patient’s life, Effective, fastacting, GPP-specific therapies are needed to control them.⁴

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Volcano bursting through dermatologist’s door

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UNDERSTANDING GPP

Explore characteristics of GPP and what makes it distinct from Plaque Psoriasis.⁵

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RECOGNISING GPP FLARES

Learn the signs and symptoms of GPP flares.

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THE IMPACT OF GPP

GPP flares can affect every aspect of patients’ lives.⁴

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THE PATHOLOGY OF GPP

The IL-36 pathway plays a key role in the pathogenesis of GPP.⁵

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THE HIGH UNMET NEED OF GPP

Review the unmet need associated with GPP.⁴

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GPP= Generalized Pustular Psoriasis; IL36-=interleukin36-.

REFERENCES

Choon SE, Lebwohl MG, Marrakchi S, et al. Study protocol of the global Effisayil 1 Phase II, multicentre, randomised, double-blind, placebo-controlled trial of spesolimab in patients with generalized pustular psoriasis presenting with an acute flare. BMJ Open. 2021;11(3):e043666
Gooderham MJ, Van Voorhees AS, Lebwohl MG. An update on generalized pustular psoriasis. Expert Rev Clin Immunol. 2019;15(9):907-919.
Marrakchi S, Puig L. Pathophysiology of Generalized Pustular Psoriasis. Am J Clin Dermatol. 2022;23:13-19.
Strober B, Kotowsky N, Medeiros R, et al. Unmet Medical Needs in the Treatment and Management of Generalized Pustular Psoriasis Flares: Evidence from a Survey of Corrona Registry Dermatologists. Dermatol Ther (Heidelb). 2021;11(2):529-541.
Johnston A, Xing X, Wolterink L, et al. IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis. J Allergy Clin Immunol. 2017;140(1):109-120.