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Impact of GPP

THE IMPACT OF GPP

GPP FLARES CAN TAKE A TOLL ON PATIENTS1

Flares can escalate quickly with serious complications that may require hospitalisation.2 Systemic
complications affect more than just the skin and may potentially lead to multisystem organ failure.
These complications may include acute respiratory distress syndrome, sepsis, septic shock, high-output
cardiac failure, renal failure, neutrophilic cholangitis, metabolic abnormalities, and uveitis.3

GPP FLARES ARE CHALLENGING TO CONTROL AND MAY REQUIRE URGENT ATTENTION2

Signs and symptoms of a Generalized Pustular Psoriasis (GPP) flare can affect patients’ physical, emotional, and social well-being.1

physical

PHYSICAL

Symptoms as pain and discomfort are prominent during flares and may interfere with an individual’s ability to participate in physical or activities.1
In a survey of patients, 58% reported that flares impacted their physical activity.1

Emotional

EMOTIONAL

GPP can cause mental and emotional suffering.3
83% of patients reported emotional stress related to their GPP symptoms.1

Social

SOCIAL

The physical appearance of GPP flares can create a social stigma.1
41% of patients reported that flares impacted their social life and 52% intimacy with their partner.1

 

GPP FLARE DURATION AND TIME TO RESOLUTION MAY VARY3

Duration length of GPP flares
 

Post-flare, 83% of dermatologists reported that patients had residual disease.2 

Over half of dermatologists (55%) reported that their patients’
flares typically last 2 to < 4 weeks, while 41% reported
that flares typically last 1–3 months”2
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SEE HOW THE IL36- PATHWAY
PLAYS A ROLE IN GPP

Find out more

GPP= Generalized pustular psoriasis; IL36-=interleukin36-.

REFERENCES

  1. Reisner DV, Johnsson FD, Kotowsky N, Brunette S, Valdecantos W, Eyerich K. Impact of Generalized Pustular Psoriasis from the Perspective of People Living with the
    Condition: Results of an Online Survey. Am J Clin Dermatol. 2022;23:65-71. 

  2. Strober B, Kotowsky N, Medeiros R, et al. Unmet Medical Needs in the Treatment and Management of Generalized Pustular Psoriasis Flares: Evidence from a Survey of
    Corrona Registry Dermatologists. Dermatol Ther (Heidelb). 2021;11(2):529-541. 

  3. Kharawala S, Golembesky AK, Bohn RL, Esser D. The clinical, humanistic, and economic burden of generalized pustular psoriasis: a structured review. Expert Rev Clin
    Immunol. 2020;16(3):239-252. 

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