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The Il-36 pathway plays a key role in the pathogenesis of GPP

THE PATHOLOGY OF GPP1

THE IL-36 PATHWAY PLAYS A KEY ROLE IN THE PATHOGENESIS OF GPP1

GPP IS DRIVEN BY THE IL-36 PATHWAY2

IL-36 agonists bind to the IL-36 receptor, or IL-36R, on keratinocyte surfaces, promoting IL-36 expression. This pathway regulates the expression of numerous cytokines, triggering a pro-inflammatory cycle.3

IL-36 agonists bind to the IL-36 receptor, or IL-36R.

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THE IL-36 PATHWAY IS REGULATED BY THE INTERPLAY BETWEEN IL-36 AGONISTS AND ANTAGONISTS4

Any imbalance between IL-36 agonists and antagonists causes dysregulation in the IL-36 pathway. Unregulated IL-36R signalling leads to uncontrolled induction of downstream inflammatory cytokines, which play a key role in the pathogenesis of GPP.5

Any imbalance between IL-36 agonists and antagonists causes dysregulation in the IL-36 pathway.

Artist rendering

The IL-36 pathway is regulated by the interplay between the IL-36
agonists and the antagonist IL-36Ra to ensure a balanced immune
response.”
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UNDERSTAND THE HIGH UNMET NEED OF GPP6

Find out more

GPP=Generalized Pustular Psoriasis; IL=interleukin; IL1-RAcP=interleukin1- receptor accessory protein; IL36-R=IL36- receptor; IL36-Ra=interleukin 36 receptor antagonist; TIR=Toll/interleukin1- receptor.

REFERENCES

  1. Johnston A, Xing X, Wolterink L, et al. IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis. J Allergy Clin Immunol 2017;140(1):109-120

  2. Krueger J. Puig L. Thaci D - Treatment Options and Goals for Patients with Generalized Pustular Psoriasis. American Journal of Clinical Dermatology (2022) . Suppl 1):S51–S64) 23

  3. Goldstein JD. Bassoy EY. Caruso A. et.al. IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis. Life Science Alliance

  4. Bassoy EY, Towne JE, Gabay C. Regulation and function of interleukin36- cytokines. Immunol Rev. 178-169:(1)281;2018

  5. Marrakchi S, Guigue P, Renshaw BR, et al. Interleukin36-–receptor antagonist deficiency and generalized pustular psoriasis. N Engl J Med. 628-620:(77)365;2011

  6. Strober B, Kotowsky N, Medeiros R, et al. Unmet medical needs in the treatment and management of generalized pustular psoriasis flares: evidence from a survey of Corrona registry dermatologists. Dermatol Ther (Heidelb). 541-529:(2)11;2021

Egypt GPP QR Code-ONA665-08022023