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Why Glyxambi®?

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Powerful Efficacy.
Ensured Safety.
Convenient Dosing.

Pleiotropic benefits

Reduction in body weight with Empagliflozin + Linagliptin1*#

pleiotropic

Glyxambi® is not indicated for treatment of HF or CKD. * Nominal p-value. † The 38% RRR in CV death was achieved in the overall EMPA-REG OUTCOME® population for the duration of the trial.

‡ Pooled data from 10 mg and 25 mg doses of Jardiance®; both doses showed a comparable reduction in the risk of CV death. # Prespecified microvascular endpoint in CARMELINA® trial.

FDC: Fixed-dose combination. CV: Cardiovascular. CVD: Cardiovascular disease. EMPA: Empagliflozin. 3P-MACE: 3-point major adverse cardiovascular events. LINA: Linagliptin. HR: Hazard ratio. RRR: Relative risk reduction. hHF: Hospitalisation due to heart failure. Cl: Confidence interval. T2DM: Type 2 diabetes mellitus. CKD: Chronic kidney disease. HF: Heart failure.

References:

  1. Zinman B, et al. N Engl J Med. 2015;373(22):2117-2128.

  2. Rosenstock J, et al. JAMA. 2019;321(1):69-79.

  3. Rosenstock J, et al. JAMA. 2019;322(12):1155-1166.

Reduction of serum uric acid levels with Empagliflozin+Linagliptin1*

pleiotropic 2

Glyxambi® is not indicated for treatment of HF or CKD. * Nominal p-value. † The 38% RRR in CV death was achieved in the overall EMPA-REG OUTCOME® population for the duration of the trial.

‡ Pooled data from 10 mg and 25 mg doses of Jardiance®; both doses showed a comparable reduction in the risk of CV death. # Prespecified microvascular endpoint in CARMELINA® trial.

FDC: Fixed-dose combination. CV: Cardiovascular. CVD: Cardiovascular disease. EMPA: Empagliflozin. 3P-MACE: 3-point major adverse cardiovascular events. LINA: Linagliptin. HR: Hazard ratio. RRR: Relative risk reduction. hHF: Hospitalisation due to heart failure. Cl: Confidence interval. T2DM: Type 2 diabetes mellitus. CKD: Chronic kidney disease. HF: Heart failure.

References:

  1. Zinman B, et al. N Engl J Med. 2015;373(22):2117-2128.

  2. Rosenstock J, et al. JAMA. 2019;321(1):69-79.

  3. Rosenstock J, et al. JAMA. 2019;322(12):1155-1166.

Reduction in blood pressure with Empagliflozin+Linagliptin1*#

pleiotropic 3

# Exploratory endpoint.

FDC: Fixed-dose combination. EMPA: Empagliflozin. LINA: Linagliptin. SE: Standard error. SBP: Systolic blood pressure. DBP: Diastolic blood pressure. BP: Blood pressure.

Reference:

  1. DeFronzo RA, et al. Diabetes Care. 2015;38(3):384-393. (Based on subgroup analysis of patients with HbA1c ≥8.5% at baseline).

Disclaimer:
  • Glyxambi is not indicated for weight or serum uric acid reduction. 
  • Glyxambi is not indicated for BP reduction.