WHEN GPP WALKS IN THE DOOR
Learn the facts. Generalized Pustular Psoriasis (GPP) is a rare neutrophilic skin disease characterised by episodes of widespread eruptions of sterile pustules and erythematous skin that can occur with or without systemic inflammation.1-3 This website can help you learn more about GPP, including its underlying causes, the impact flares have on patients, and the challenges of effective treatment.
![Volcano bursting through dermatologist’s door](/mea/ae/disease/gpp/sites/default/files/2022-02/background-image%402x.jpg)
![Doctor Close-Up](/mea/ae/disease/gpp/sites/default/files/2022-02/01-elements-placeholder-card-16-9.png)
UNDERSTANDING GPP
Discover the underlying causes of GPP and what makes it distinct from Plaque Psoriasis.2,3
![Volcano close-up](/mea/ae/disease/gpp/sites/default/files/2022-02/01-elements-placeholder-card-16-9_0.png)
THE PATHOLOGY OF GPP
Discover the role the IL-36 pathway plays in GPP.4
![Fire close-up](/mea/ae/disease/gpp/sites/default/files/2022-02/01-elements-placeholder-card-16-9_1.png)
RECOGNISING GPP FLARES
Learn the signs and symptoms of GPP flares, and the clinical burden of trying to control them.5-7
References
-
1.
Choon SE, Lebwohl MG, Marrakchi S, et al. Study protocol of the global Effisayil 1 phase II, multicentre, randomised, double-blind, placebo-controlled trial of spesolimab in patients with generalized pustular psoriasis presenting with an acute flare. BMJ Open. 2021;11(3):e043666. doi:10.1136/bmjopen-2020-043666
-
2.
Navarini AA, Burden AD, Capon F, et al; for the ERASPEN Network. European consensus statement on phenotypes of pustular psoriasis. J Eur Acad Dermatol Venereol. 2017;31(11):1792-1799. doi:10.1111/jdv.14386
-
3.
Benjegerdes KE, Hyde K, Kivelevitch D, Mansouri B. Pustular psoriasis: pathophysiology and current treatment perspectives. Psoriasis (Auckl). 2016;6:131-144. doi:10.2147/PTT.S98954
-
4.
Johnston A, Xing X, Wolterink L, et al. IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis. J Allergy Clin Immunol. 2017;140(1):109-120. doi:10.1016/j.jaci.2016.08.056
-
5.
Strober B, Kotowsky N, Medeiros R, et al. Unmet medical needs in the treatment and management of generalized pustular psoriasis flares: evidence from a survey of Corrona registry dermatologists. Dermatol Ther (Heidelb). 2021;11(2):529-541. doi:10.1007/s13555-021-00493-0
-
6.
Gooderham MJ, Van Voorhees AS, Lebwohl MG. An update on generalized pustular psoriasis. Expert Rev Clin Immunol. 2019;15(9):907-919. doi:10.1080/1744666X.2019.1648209
-
7.
Ly K, Beck KM, Smith MP, Thibodeaux Q, Bhutani T. Diagnosis and screening of patients with generalized pustular psoriasis. Psoriasis (Auckl). 2019;9:37-42. doi:10.2147/PTT.S181808