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Impact of GPP

THE IMPACT OF GPP

GPP FLARES CAN TAKE A TOLL ON PATIENTS1,2

Flares can escalate quickly with serious complications that may require hospitalisation. Systemic complications affect more than just the skin and may potentially lead to multisystem organ failure. These complications may include acute respiratory distress syndrome, sepsis, cardiovascular aseptic shock, high-output cardiac failure, renal failure, neutrophilic cholangitis, metabolic abnormalities, osteoarthritis, and uveitis.1-7

GPP FLARES ARE CHALLENGING TO CONTROL AND MAY REQUIRE URGENT ATTENTION2-4

Signs and symptoms of a Generalized Pustular Psoriasis (GPP) flare can affect patients’ physical, emotional, and social well-being.1,3,8-10

physical

PHYSICAL

Symptoms of GPP such as itching and pain can affect patients’ daily lives.1,8
In a survey of patients, 58% reported that flares impacted their physical activity.11

Emotional

EMOTIONAL

GPP can cause mental and emotional suffering.9,10
83% of patients reported emotional stress related to their GPP symptoms.11

Social

SOCIAL

The physical appearance of GPP flares can create a social stigma.1,3,8,9
41% of patients reported that flares impacted their social life and 52% intimacy with their partner.11

GPP FLARE DURATION AND TIME TO RESOLUTION MAY VARY3

Duration length of GPP flares

In a survey using the CorEvitas Psoriasis Registry, 83% of dermatologists reported that patients had residual disease.3

DR GOODERHAM PROVIDES MORE INSIGHT ON HOW LONG FLARES MAY LAST

Most flares last between 2 to 5 weeks, but may persist longer than 3 months.”
Dr Melinda Gooderham
REFERENCES

  1. Kharawala S, Golembesky AK, Bohn RL, Esser D. The clinical, humanistic, and economic burden of generalized pustular psoriasis: a structured review. Expert Rev Clin Immunol. 2020;16(3):239-252. doi:10.1080/1744666X.2019.1708193 

  2. Gooderham MJ, Van Voorhees AS, Lebwohl MG. An update on generalized pustular psoriasis. Expert Rev Clin Immunol. 2019;15(9):907-919. doi:10.1080/1744666X.2019.1648209 

  3. Strober B, Kotowsky N, Medeiros R, et al. Unmet medical needs in the treatment and management of generalized pustular psoriasis flares: evidence from a survey of Corrona registry dermatologists. Dermatol Ther (Heidelb). 2021;11(2):529-541. doi:10.1007/s13555-021-00493-0 

  4. Ly K, Beck KM, Smith MP, Thibodeaux Q, Bhutani T. Diagnosis and screening of patients with generalized pustular psoriasis. Psoriasis (Auckl). 2019;9:37-42. doi:10.2147/PTT.S181808 

  5. Bachelez H. Pustular psoriasis and related pustular skin diseases. Br J Dermatol. 2018;178(3):614-618. doi:10.1111/bjd.16232 

  6. Bachelez H. Pustular psoriasis: the dawn of a new era. Acta Derm Venereol. 2020;100(3):adv00034. doi:10.2340/00015555-3388

  7. Choon SE, Lai NM, Mohammad NA, Nanu NM, Tey KE, Chew SF. Clinical profile, morbidity, and outcome of adult-onset generalized pustular psoriasis: analysis of 102 cases seen in a tertiary hospital in Johor, Malaysia. Int J Dermatol. 2014;53(6):676-684. doi:10.1111/ijd.12070

  8. Skalicky A, Rentz A, Esser D, Thoma C, Gloede T. Symptom experience of patients with generalized pustular psoriasis (GPP). Value in Health. 2020;23(suppl 1):S345. Abstract: PRO89. doi:10.1016/j.jval.2020.04.1310 

  9. Sampogna F, Tabolli S, Söderfeldt B, Axtelius B, Aparo U, Abeni D; for the IMPROVE Investigators. Measuring quality of life of patients with different clinical types of psoriasis using the SF-36. Br J Dermatol. 2006;154(5):844-849. doi:10.1111/j.1365-2133.2005.07071.x 

  10. Kotowsky N, Gao R, Singer D, Garry E, Golembesky AK. Healthcare resource utilization (HCRU) in patients with generalized pustular psoriasis (GPP): a claims database study. Value in Health. 2020;23(suppl 1):S333-S334. Abstract: PRO29. doi:10.1016/j.jval.2020.04.1257 

  11. Kotowsky N, Brunette SR, Valdecantos WC. Insights from patients with generalized pustular psoriasis: results of an online survey in the USA. Poster presented at: 30th European Academy of Dermatology and Venereology Congress; September 29-October 2, 2021; virtual.