Mode of action

Mode of action

Tenecteplase is a recombinant fibrin-specific plasminogen activator that is derived from native tissue plasminogen activator (t-PA) through modifications at three sites of the protein structure. It binds to the fibrin component of the thrombus (blood clot) and selectively converts thrombus-bound plasminogen to plasmin. Plasmin degrades the fibrin mesh thereby dissolving the clot. 

Compared to native t-PA, Metalyse^® has a higher fibrin specificity and greater resistance to inactivation by its endogenous inhibitor (PAI-1).¹