ACTILYSE®
Mechanism of action
The active ingredient of ACTILYSE®, alteplase, is a recombinant human tissue-type plasminogen activator, a glycoprotein, which activates plasminogen directly to plasmin. When administered intravenously, alteplase remains relatively inactive in the circulatory system. Once bound to fibrin, it is activated, inducing the conversion of plasminogen to plasmin leading to the dissolution of the fibrin clot.
References:
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ACTILYSE® Injection, approved package insert. Updated April 2019. Approved September 2019.
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