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For Healthcare Professionals

JARDIANCE DUO®

Dosing and administration

Recommended dosage

Adjust dosing based on effectiveness and tolerability while not exceeding the maximum recommended daily dose of metformin hydrochloride 2,000 mg and empagliflozin 25 mg.

Individualize the starting dose of JARDIANCE DUO® based on the patient’s current regimen:

  • In patients on metformin hydrochloride
    switch to JARDIANCE DUO® containing empagliflozin 5 mg with a similar total daily dose of metformin hydrochloride
  • In patients on empagliflozin
    switch to JARDIANCE DUO® containing metformin hydrochloride 500 mg with a similar total daily dose of empagliflozin
  • In patients already treated with empagliflozin and metformin hydrochloride
    switch to JARDIANCE DUO® containing the same total daily doses of each component.

Administration

  • Take JARDIANCE DUO® twice daily with meals; with gradual dose escalation to reduce the gastrointestinal side effects due to metformin.

Reference:

  1. JARDIANCE DUO® approved package insert. Updated in December 2020 and approved in June 2021.

Reporting adverse events

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