SPIOLTO® RESPIMAT®

SPIOLTO® RESPIMAT® is a fixed dose combination inhalation solution containing the long-acting muscarinic receptor antagonist (LAMA), tiotropium and the long-acting beta₂-agonist (LABA), olodaterol which is delivered via the SPIOLTO® RESPIMAT® soft mist inhaler device.¹

The two active ingredients provide additive bronchodilation due to their different modes of action.¹ Since muscarinic receptors appear to be more prominent in the central airways while beta₂-adrenoceptors have a higher expression level in the peripheral airways, a combination of tiotropium and olodaterol should provide optimal bronchodilatation in all regions of the lungs.¹

Tiotropium - Tiotropium bromide is a long-acting, specific antagonist at muscarinic receptors.¹

Olodaterol - Olodaterol has a high affinity and high selectivity to the human beta₂-adrenoceptor.¹