Acute Interstitial Pneumonia
DIAGNOSIS
SYMPTOMS
- Prominent diffuse crackles1
- Severe exertional dyspnea that develops over a short period of time1
- Median time from first symptom to presentation is 3 weeks1
- Fever, cough, shortness of breath that increase in severity over 7-14 days, progressing to respiratory failure4
DIAGNOSTIC TESTS
Pulmonary function tests1
- Restrictive pattern
- Reduced DLco
HRCT5
- Features: Exudative phase shows ground-glass opacities, airspace consolidation; organizing phase shows bronchial dilatation, architectural distortion
- Distribution: Lower lung predominance, symmetric, bilateral
Surgical lung biopsy is typically used to diagnose AIP4
- Histopathology pattern shows diffuse alveolar damage5
- Exudative early phase shows hyaline membranes and diffuse alveolar infiltration by lymphocytes5
- Proliferating phase shows alveolar wall thickening due to fibrosis and pneumocyte hyperplasia5
Chest X-ray1
- Most common findings on chest X-ray are bilateral airspace opacification with air bronchograms
- The distribution is often patchy, with sparing of the costophrenic angles