SJÖGREN’S SYNDROME - DIAGNOSIS

DIAGNOSIS

SYMPTOMS

  • Symptoms of Sjögren’s syndrome include:1,2,4
    • Objective dryness in ocular and/or oral cavities
    • Possible extraglandular manifestations:
      • Renal tubular disorders
      • Vasculitis
      • Raynaud’s phenomenon
      • Neurological manifestations
      • Pulmonary involvement

DIAGNOSTICS

For Sjögren’s Syndrome1,6 For Sjögren’s Syndrome-ILD1,7
Established diagnosis of Sjögren’s syndrome
OR
medical history + thorough physical exam + serologies (eg, antinuclear antibodies (ANA), anti-Ro antibodies/SSA (anti-Ro/SSA), anti-La antibodies/SSB (anti-La/SSB), RF, ESR) + eye tests (Schirmer, Rose Bengal) + minor salivary gland biopsy
PFTs HRCT Lung Biopsy BAL
Restrictive defect (or mixed, if other comorbidities present); reduced DLCO NSIP,
Ground-glass opacities, subpleural small nodules, nonseptal linear opacities, interlobular septal thickening, bronchiectasis, cysts
Not always necessary Primarily for exclusion of other causes

See also

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Interstitial lung disease in systemic sclerosis with a focus on chest CT

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