IPF can be more deadly than many cancers2,3

5-year survival rate in IPF vs types of cancer

5-year survival rate in IPF vs types of cancer chart 5-year survival rate in IPF vs types of cancer chart

Pulmonary fibrosis can become progressive in ILDs other than IPF and is associated with a poor prognosis4

Interstitial lung diseases (ILDs) with progressive pulmonary fibrosis behave in a clinically similar way to idiopathic pulmonary fibrosis (IPF). Approximately 1 out of 4 patients with non-IPF ILD may develop progressive pulmonary fibrosis, according to an online survey of physicians.4-7

Progressive pulmonary fibrosis is characterized by4,7:

downwards arrow icon

Lung function
decline

worsening respiratory icon

Worsening respiratory
symptoms

worsening quality icon

Worsening
quality of life

early mortality icon

Early
mortality

Progressive pulmonary fibrosis in ILDs can be deadly8-18

survival rate chart survival rate chart

Fibrosis, or scarring, is chronic and irreversible,
making early recognition and referral
critical in ILD1,19,20

question mark graphic question mark graphic Recognize signs of ILD
stethoscope and person graphic stethoscope and person graphic Learn about reviewing tests and scans
book graphic book graphic View resources

HP, hypersensitivity pneumonitis; RA-ILD, rheumatoid arthritis interstitial lung disease; SSc-ILD, systemic sclerosis-associated interstitial lung disease; uILD, unclassifiable interstitial lung disease.

References

  1. Oldham JM, Noth I. Respir Med. 2014;108(6):819-829.
  2. Vancheri C et al. Eur Respir J. 2010;35(3):496-504.
  3. Fujimoto H et al. Clin Med Insights Circ Respir Pulm Med. 2015;9(S1):179-185.
  4. Wells AU et al. Eur Respir J. 2018;51(5):1800692.
  5. Wijsenbeek M et al. Curr Med Res Opin. 2019;35(11):2015-2024.
  6. Cottin V et al. Eur Respir Rev. 2019;28(151):180100.
  7. Cottin V et al. Eur Respir Rev. 2018;27(150):180076.
  8. Ryerson CJ et al. Eur Respir J. 2013;42:750-757.
  9. Hyldgaard C et al. Respirology. 2017;22(3):494-500.
  10. Wells AU et al. Am J Respir Crit Care Med. 1994;149(6):1583-1590.
  11. Mapel DW et al. Thorax. 1998;53(6):469-476.
  12. Hubbard R et al. Chest. 1998;113(2):396-400.
  13. Goh NSL et al. Am J Respir Crit Care Med. 2008;177(11):1248-1254.
  14. Moore OA et al. Rheumatology. 2013;52(1):155-160.
  15. Kim EJ et al. Eur Respir J. 2010;35(6):1322-1328.
  16. Bongartz T et al. Arthritis Rheum. 2010;62(6):1583-1591.
  17. Gimenez A et al. Thorax. 2018;73(4):391-392.
  18. Vourlekis JS et al. Am J Med. 2004;116(10):662-668.
  19. Wollin L et al. Eur Respir J. 2019;54(3):1900161.
  20. Selman M et al. Ann Intern Med. 2001;134(2):136-151.
  21. Ryu JH et al. Mayo Clin Proc. 2007;82(8):976-986.
  22. Cosgrove GP et al. BMC Pulm Med. 2018;18(1):9.