Usual Interstitial Pneumonia Criteria | IPF Radiology Rounds

Criteria for UIP Pattern

Usual interstitial pneumonia is the most common idiopathic interstitial pneumonia³¹ and carries the worst prognosis.³⁰ UIP is the radiologic and pathologic pattern observed in patients with IPF,⁴⁵ but UIP-like patterns are also caused by secondary conditions such as collagen vascular disease, chronic hypersensitivity pneumonitis, asbestosis, or drug toxicity,^32,33 highlighting the importance of identifying any possible causes of lung disease prior to diagnosing idiopathic UIP.⁴⁵

HRCT Interpretation Algorithm for Suspected Fibrotic Interstitial Lung Disease

UIP Pattern

Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline

Reference

30. Travis WD, Matsui K, Moss J, Ferrans VJ. Idiopathic nonspecific interstitial pneumonia: prognostic significance of cellular and fibrosing patterns: survival comparison with usual interstitial pneumonia and desquamative interstitial pneumonia. Am J Surg Pathol. 2000;24:19-33.

31. Spagnolo P, Tonelli R, Cocconcelli E, Stefani A, Richeldi L. Idiopathic pulmonary fibrosis: diagnostic pitfalls and therapeutic challenges. Multidiscip Respir Med. 2012;7:42.

32. Takemura T, Akashi T, Kamiya H, et al. Pathological differentiation of chronic hypersensitivity pneumonitis from idiopathic pulmonary fibrosis/usual interstitial pneumonia. Histopathology. 2012;61:1026-1035.

33. Glazer CS, Newman LS. Occupational interstitial lung disease. Clin Chest Med. 2004;25:467-478.

45. Raghu G, Remy-Jardin M, Myers JL, et al. Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline. Am J Respir Crit Care Med. 2018;198(5):e44-e68.