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Role of DLL3

DLL3 is an inhibitory Notch ligand that is expressed in tumors with a neuroendocrine origin, such as small-cell lung cancer (SCLC), Large Cell Neuroendocrine Carcinoma of the Lung (LCNEC), glioma, etc. – but not in normal adult tissue.1‒3 Notch pathway signaling is involved in a variety of development processes, including the development of pulmonary neuroendocrine cells.2 DLL3 expression inhibits Notch signaling, which is downregulated during neuroendocrine tumor growth.2

  1. National Center for Biotechnology Information. DLL3 delta like canonical Notch ligand 3 [Homo sapiens (human)]. https://www.ncbi.nlm.nih.gov/gene/10683 (Accessed: February 2024).

  2. Owen DH, et al. J Hematol Oncol. 2019;12(1):61.

  3. Saunders LR, et al. Sci Transl Med, 2015;7(302):302ra136.