Elementary Lesions

Centrilobular Micronodulation

Branching Centrilobular Micronodulations (Tree-in-Bud Pattern) of Bronchiolar origin are associated with different conditions

• Infectious bronchiolitis

  • tuberculosis, atypical mycobacteria, cytomegalovirus, Aspergillus, Candida, and other bacteria

• Aspiration, inhalation (gas, smoke)

• Follicular bronchiolitis

  • Sjögren’s syndrome, rheumatoid arthritis, immune system deficiencies

• Bronchiectasis, cystic fibrosis, primary ciliary dyskinesia, allergic bronchopulmonary aspergillosis, panbronchiolitis, constrictive bronchiolitis

Centrilobular Micronodules can also be associated with vascular and perivascular diseases

• Vasculitis (granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis)

• Endovascular metastases

• Pulmonary haemorrhage

  • miliary mycosis (aspergillosis, candidosis)

  • virosis (herpes, Cytomegalovirus)